We propose an initial model and a method that enable to synthetically engineer a consortium for the production of compounds that are either exogenous to it, or are endogenous but where the interaction could be beneficial. This model and software associated have been published in Scientific Reports , the paper is available here.

Download Release 0.2.0

MultiPus Release 0.2.0 (2016-05-17)

This new release uses an ASP solver to speed up the resolution process. In the release are included the pre-processing and post-processing steps. After the post-processing step, the solutions can be visualized using DINGHY

Download Release 0.1.0

MultiPus Release 0.1.0 (2016-02-19)

Download Datasets

We applied the model to two cases of application as described in the paper. Related networks are available below. All were obtained from KEGG using MetExplore.

Production of antibiotics

Joint production of 1,3-propanediol and methane

Authors:

Alice Julien-Laferrière, Laurent Bulteau, Delphine Parrot, Alberto Marchetti-Spaccamela, Leen Stougie, Susana Vinga, Arnaud Mary, and Marie-France Sagot